Recombinant Protein DT3C


Recombinant Protein DT3C

Known as Diphtheria Toxin Fragment A-Diphtheria Toxin Fragment C (DTA-DTC), has several applications primarily due to its ability to selectively kill cells expressing specific surface markers.


Features 

Modular Structure

DT3C is a fusion protein consisting of Diphtheria Toxin Fragment A (DTA) linked to Diphtheria Toxin Fragment C (DTC). 



Potent Cytotoxic Activity

DTA, the enzymatic domain of DT3C, possesses potent cytotoxic activity by inhibiting protein synthesis in cells

 

Selective Cytotoxicity

DT3C exhibits selective cytotoxicity towards cells expressing specific surface markers or antigens. 



Applications

Targeted Cell Ablation:

T3C can be used for targeted cell ablation in cell culture systems, animal models, and potentially in clinical settings.


Creation of Knockout Animal

 Models

DT3C can be used to generate knockout animal models by selectively ablating cells expressing a particular gene of interest

Cancer Therapy

DT3C has potential applications in cancer therapy, particularly in targeted cancer treatment strategies

 


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