AffiREC® SARS-CoV-2 (501.V2) Stabilized Spike Glycoprotein (Full-Length), His-streptavidin Tag (HEK293)

Overview:

SARS-CoV-2 HexaPro stabilized Spike glycoprotein containing amino acid changes in accordance with variant 501.V2 (“South African variant”) : D80A, D215G, K417N, E484K, N501Y, A701V relative to Wuhan-Hu-1. This protein has the polybasic furin cleavage site “RRAR” changed to “SRAS” to prevent furin cleavage of the target protein. The protein also contains 6 amino acid changes to proline and a C-terminal T4 fibritin trimerization domain to stabilize the protein in its pre-fusion conformation as described in Hsieh, Goldsmith et al. 2020. The protein was produced in HEK293 and purified from culture supernatant.