ADRB Recombinant Proteins 

ADRB (Adrenergic Receptor Beta) recombinant proteins are engineered forms of the beta-adrenergic receptors, which belong to the G-protein-coupled receptor (GPCR) family. These receptors are critical in mediating the physiological responses to adrenaline and noradrenaline, including regulation of heart rate, smooth muscle relaxation, and metabolic processes. 

Content on ADRB Recombinant Proteins
  • Structure and Function
    • Beta-adrenergic receptors are integral membrane proteins characterized by:
      • Seven transmembrane domains: Enable signal transduction across the cell membrane.
      • Extracellular ligand-binding domain: Binds to adrenaline or synthetic agonists/antagonists.
      • Intracellular G-protein coupling domain: Activates downstream signaling pathways, primarily the cAMP-PKA pathway.
    • Subtypes include:
      • ADRB1: Predominantly expressed in the heart, regulates cardiac output.
      • ADRB2: Widely distributed, involved in smooth muscle relaxation and metabolic regulation.
      • ADRB3: Found in adipose tissue, mediates lipolysis and thermogenesis.
Applications of ADRB Recombinant Proteins
  • Drug Discovery and Development
    • Screen agonists or antagonists targeting specific ADRB subtypes for therapeutic applications in cardiovascular diseases, asthma, or metabolic disorders.
    • Test beta-blockers and other cardiovascular drugs for their affinity and efficacy on ADRB1 and ADRB2.
  • Cardiovascular Research
    • Study ADRB1-mediated regulation of heart rate, contractility, and cardiac hypertrophy.
    • Explore ADRB2’s role in vascular tone modulation and its therapeutic potential in hypertension and heart failure.
  • Metabolic and Obesity Research
    • Investigate ADRB3’s role in lipolysis, energy expenditure, and thermogenesis in adipose tissue.
    • Analyze its potential as a target for anti-obesity and metabolic syndrome therapies.

ADRB recombinant proteins are indispensable tools for advancing research in cardiovascular, metabolic, and neurological fields, offering critical insights into adrenergic signaling and therapeutic targeting.

2,834.50 2834.5 USD