SCP Recombinant Proteins 

SCP (Secreted Cysteine-rich Protein) recombinant proteins are engineered forms of the SCP family of proteins, which are characterized by their cysteine-rich domains and diverse biological roles. SCP proteins are involved in various physiological and pathological processes, including cellular signaling, extracellular matrix interactions, and immune responses. Recombinant SCP proteins are essential tools for studying their structure, function, and therapeutic potential in research and clinical applications.

Content of SCP Recombinant Proteins

• Expression Systems:
  • Mammalian Systems: Used for producing full-length SCP proteins with native post-translational modifications (e.g., glycosylation).
  • Bacterial Systems: Suitable for producing truncated forms or individual domains for structural and functional studies.
  • Insect Systems: Employed for large-scale production of functionally active proteins.
• Validation and Characterization:
  • Verified through biochemical assays for activity and structural integrity using SDS-PAGE, mass spectrometry, and functional binding studies.
  • Assessed for folding and disulfide bond formation, critical for cysteine-rich proteins.

Applications of SCP Recombinant Proteins

• Structural Biology:
  • Determine the structure of SCP proteins or domains using crystallography or cryo-electron microscopy to elucidate their functional mechanisms.
  • Use recombinant SCP proteins to study protein-protein or protein-ligand interactions.
• Drug Discovery and Screening:
  • High-throughput screening of small molecules or antibodies targeting SCP proteins for therapeutic applications in cancer, fibrosis, or inflammatory diseases.
  • Develop peptide-based inhibitors mimicking SCP domains to modulate their activity.
• Immune Response Modulation:
  • Investigate SCP proteins' role in immune system regulation and inflammatory responses.
  • Use recombinant SCP proteins as potential immunomodulators in autoimmune or infectious disease models.
• Biomarker Discovery:
  • Validate SCP proteins as biomarkers for specific diseases, such as cancer or fibrosis, using recombinant forms in diagnostic assays.

Recombinant SCP proteins are invaluable tools for understanding their diverse roles in cell biology and disease, enabling advancements in therapeutic and diagnostic development.