ANGPTL Recombinant Proteins 

ANGPTL recombinant proteins refer to synthetic versions of Angiopoietin-like proteins (ANGPTL), a family of secreted glycoproteins structurally similar to angiopoietins but with distinct biological roles. These proteins are involved in lipid metabolism, angiogenesis, and stem cell regulation. ANGPTLs are crucial in research focusing on cardiovascular diseases, metabolic disorders, and cancer biology. Recombinant technology enables the production of highly purified ANGPTL proteins, ensuring their structural and functional integrity for research and therapeutic applications.

Technical Content
  • Production and Features:
    • Recombinant ANGPTLs are typically expressed in mammalian cells (e.g., HEK293) for proper glycosylation or in E. coli for non-glycosylated forms.
    • Common purification tags include His-tag or Fc-tag, facilitating easy purification and functional assays.
    • High purity levels (>95%) are achieved using affinity chromatography and validated with SDS-PAGE and Western Blot.
  • Quality Assurance:
    • Verified for bioactivity in functional assays, such as lipoprotein lipase inhibition assays for ANGPTL4.
    • Endotoxin levels controlled (<0.1 EU/µg) for sensitive biological applications.
Applications of ANGPTL Recombinant Proteins
  • Metabolic Research:
    • Studying the regulation of triglyceride metabolism and its link to metabolic diseases like hyperlipidemia and diabetes.
    • ANGPTL3 and ANGPTL4 are prime candidates for developing therapeutic inhibitors targeting dyslipidemia.
  • Angiogenesis and Tumor Biology:
    • ANGPTL proteins are explored for their roles in vascular development and tumor progression.
    • ANGPTL4 is of particular interest for its involvement in metastasis, acting through endothelial permeability modulation.
  • Inflammatory Disease Models:
    • ANGPTL2 is a target for understanding chronic inflammatory pathways in diseases such as atherosclerosis and pulmonary fibrosis.
  • Stem Cell Biology:
    • ANGPTL proteins are critical in maintaining hematopoietic stem cell (HSC) quiescence and expansion, aiding regenerative medicine and bone marrow transplantation research.

ANGPTL recombinant proteins provide a versatile platform for advancing research in lipid metabolism, vascular biology, and inflammation. Their precise production ensures reliability across a range of applications, from basic research to therapeutic development, underscoring their importance in addressing key challenges in metabolic and cardiovascular diseases.

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