ASGPR Recombinant Proteins 

Asialoglycoprotein Receptor (ASGPR) is a transmembrane receptor predominantly expressed on hepatocytes. It plays a critical role in endocytosis by mediating the clearance of asialoglycoproteins from the bloodstream. The receptor recognizes terminal galactose and N-acetylgalactosamine residues on glycoproteins, binding with high specificity. 

Content of ASGPR Recombinant Protein
  • Structure:
    • Typically includes the extracellular domain of ASGPR to facilitate ligand-binding studies.
    • Commonly expressed in HEK293, CHO, or E. coli systems, with mammalian systems providing glycosylated forms for native-like functionality.
    • May be available with affinity tags (e.g., His, FLAG) for easy purification and detection.
  • Physical and Biochemical Properties:
    • Molecular Weight: Approximately 30–50 kDa, depending on glycosylation status.
    • Stability: Supplied in lyophilized or liquid form for extended storage and activity.
    • Solubility: Soluble in physiological buffers for use in functional assays.
    • Endotoxin Levels: Maintained below 1 EU/µg to ensure compatibility with sensitive systems.
Applications of ASGPR Recombinant Protein
  • Hepatocyte Research:
    • Used to study ASGPR's role in hepatocyte-specific endocytosis.
    • Enables exploration of receptor-mediated uptake mechanisms and liver function.
  • Disease Research:
    • Helps elucidate ASGPR's involvement in liver diseases such as hepatocellular carcinoma, liver fibrosis, and autoimmune liver disorders.
    • Used to study autoimmune antibodies targeting ASGPR in autoimmune hepatitis.
  • Structural and Functional Studies:
    • Facilitates research on the molecular interactions between ASGPR and its ligands.
    • Supports structural biology studies, including crystallography and cryo-EM, to understand receptor-ligand binding.

Recombinant ASGPR proteins are valuable tools for advancing our understanding of liver-specific receptor biology, designing hepatocyte-targeted therapies, and investigating ASGPR-related diseases. Their high purity and functional integrity ensure reliability in basic and translational research applications.

2,028.00 2028.0 USD
600.00 600.0 USD
1,248.00 1248.0 USD
1,488.50 1488.5 USD