ATF Recombinant Proteins 

ATF (Activating Transcription Factor) recombinant proteins are engineered versions of transcription factors from the ATF/CREB family. These proteins regulate gene expression by binding to cAMP response elements (CRE) in DNA. ATF proteins are involved in diverse biological processes, including stress response, apoptosis, metabolism, and cellular differentiation. 

Content on ATF Recombinant Proteins

• Structure and Function
  • ATF proteins are basic leucine zipper (bZIP) transcription factors, characterized by:
    • DNA-binding Domain: Recognizes CRE sequences in promoter regions.
    • Leucine Zipper Domain: Facilitates dimerization with other ATF or CREB proteins.
  • Key family members include:
    • ATF1: Regulates gene expression in response to cAMP signaling.
    • ATF2: Modulates stress and DNA damage responses, often implicated in cancer.
    • ATF4: Mediates cellular stress responses, particularly during endoplasmic reticulum (ER) stress.

Applications of ATF Recombinant Proteins

• Stress Response Research
  • Study ATF4’s role in the integrated stress response (ISR) pathway during nutrient deprivation or ER stress.
  • Explore ATF2’s involvement in stress-induced apoptosis and DNA repair mechanisms.
• Cancer Research
  • Investigate ATF2’s oncogenic or tumor-suppressive roles in various cancers.
  • Study ATF proteins as mediators of chemotherapy resistance through stress-adaptive gene regulation.
• Drug Discovery and Screening
  • Screen small molecules or peptides targeting ATF-DNA interactions or dimerization.
  • Develop inhibitors of ATF-mediated transcription for therapeutic applications in cancer or metabolic disorders.

ATF recombinant proteins are critical tools for understanding transcriptional regulation, cellular stress responses, and their roles in health and disease, offering insights into potential therapeutic targets and regulatory mechanisms.