BDNF Recombinant Proteins 

Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family, essential for neuronal survival, growth, differentiation, and synaptic plasticity. Recombinant BDNF proteins are critical tools for studying the molecular mechanisms underlying neurodevelopment, neurodegeneration, and synaptic function. 

Content

  • Structure and Function:
    • BDNF is a 27-kDa dimeric protein that binds to the TrkB receptor and p75 neurotrophin receptor to mediate downstream signaling.
    • It promotes neuronal survival, axonal growth, synaptogenesis, and plasticity.
    • Dysregulation of BDNF levels is implicated in various neurodegenerative and psychiatric disorders.
  • Expression Systems:
    • Mammalian Systems: Preferred for producing biologically active BDNF with native post-translational modifications.
    • Bacterial Systems (e.g., E. coli): Cost-effective production but lacks proper glycosylation.
    • Yeast Systems: Provide a balance between scalability and post-translational modification fidelity.

Applications

  • Neuroscience Research:
    • Investigating the role of BDNF in neurodevelopment, synaptic plasticity, and long-term potentiation (LTP).
    • Understanding BDNF's involvement in neuroprotection and regeneration after injury.
  • Drug Discovery and Screening:
    • Screening small molecules or peptides that mimic or enhance BDNF activity.
    • Developing inhibitors or modulators of BDNF signaling for therapeutic purposes.
  • Therapeutic Development:
    • Testing the potential of BDNF or its analogs as therapeutics in neurodegenerative or psychiatric disorders.
    • Evaluating delivery systems for BDNF-based therapies, such as gene therapy or nanoparticles.

BDNF recombinant proteins are pivotal in advancing our understanding of neuronal health and disease, offering critical insights into therapeutic strategies for neurodegenerative and psychiatric disorders. Their high biological relevance and versatility make them indispensable tools in modern neuroscience research.

AffiREC® Recombinant Human BDNF Protein, No Tag
CAT# AFG-KMD-20183
Size: 100 μg
1,488.50 1488.5 USD
AffiREC® BDNF
CAT# AFG-NRM-0175
Size: 100 ug
642.75 642.75 USD
AffiREC® Recombinant feline BDNF protein
CAT# AFG-GNS-4418
Size: 5 mg
607.50 607.5 USD
AffiREC® Recombinant Hamster BDNF Protein
CAT# AFG-GNS-6486
Size: 5 µg
607.50 607.5 USD
AffiREC® Recombinant Equine BDNF protein
CAT# AFG-GNS-0528
Size: 5 µg
607.50 607.5 USD
398.50 398.5 USD
398.50 398.5 USD
398.50 398.5 USD
AffiREC® Recombinant Human/Murine/Rat BDNF
CAT# AFG-EPR-0271
Size: 50 µg
696.15 696.15 USD
AffiREC® Recombinant Human pro-BDNF
CAT# AFG-EPR-0095
Size: 10 µg
169.15 169.15 USD