CFHR Recombinant Proteins 

CFHR (Complement Factor H-Related) recombinant proteins are engineered to study and manipulate the complement system, a critical component of innate immunity. CFHR proteins are structurally similar to Complement Factor H (CFH), sharing domains like short consensus repeats (SCRs) responsible for their interactions with complement components and cellular receptors. 

Content on CFHR Recombinant Proteins

• Structure and Function
  CFHR proteins are encoded by the CFHR genes located within the CFH locus on chromosome 1. They consist of multiple SCR domains that bind complement components like C3b and heparin. Recombinant CFHR proteins are synthesized in prokaryotic or eukaryotic systems to preserve their functional integrity, including glycosylation patterns necessary for biological activity.
• Types of CFHR Proteins
  • CFHR1: Acts as a complement inhibitor and competes with CFH for binding sites on C3b.
  • CFHR2: Functions in complement regulation and has implications in lipid metabolism.
  • CFHR3: Modulates complement activation pathways.
  • CFHR4 and CFHR5: Participate in complement amplification and immune complex clearance.

Applications of CFHR Recombinant Proteins

• Biomarker Discovery
  CFHR proteins are analyzed for their potential as biomarkers in inflammatory and autoimmune conditions due to their differential expression in pathological states.
• Therapeutics and Diagnostics
  • Therapeutics: Used in recombinant fusion therapies for complement inhibition.
  • Diagnostics: Serve as tools in ELISA and binding assays to detect autoantibodies or measure complement activity.
• Research and Development
  CFHR recombinant proteins are crucial for studying complement-mediated cell death, immune complex formation, and microbial pathogenesis.

CFHR recombinant proteins are indispensable tools in immunological research, offering profound insights into complement biology and its implications in health and disease.