CXCL Recombinant Proteins
CXCL recombinant proteins represent a family of small cytokines, known as C-X-C motif chemokines, that play critical roles in immune cell recruitment, inflammation, and angiogenesis. CXCL proteins are essential mediators of chemotaxis, guiding neutrophils, T cells, and other immune cells to sites of infection, injury, or inflammation. Members of this family, such as CXCL8 (IL-8), CXCL10 (IP-10), and CXCL12 (SDF-1), are widely studied for their roles in cancer, autoimmune diseases, and infectious diseases.
Content of CXCL Recombinant Protein
CXCL recombinant proteins are produced in bacterial, yeast, or mammalian expression systems to ensure proper folding and biological activity. These proteins typically retain their conserved C-X-C motif and functional domains necessary for receptor binding and signaling. Recombinant forms are often tagged (e.g., His-tag or GST-tag) for purification and experimental applications.
Applications of CXCL Recombinant Protein
- Immunology Research
- Studied for their roles in immune cell chemotaxis and activation.
- CXCL10 and CXCL12 are particularly significant in T-cell and dendritic cell trafficking.
- Cancer Biology
- CXCL8 and CXCL12 are key mediators of tumor growth, metastasis, and angiogenesis.
- Recombinant CXCL proteins are used to study tumor microenvironment signaling.
- Infectious Disease Studies
- CXCL10 is a biomarker for viral infections, including hepatitis and HIV.
- CXCL recombinant proteins are employed to understand pathogen-immune system interactions.
- Drug Development and Screening
- High-throughput assays use CXCL recombinant proteins to identify inhibitors of chemokine-receptor interactions, such as CXCR4 and CXCR3 antagonists.
- Autoimmune and Inflammatory Diseases
- CXCL proteins are implicated in diseases like rheumatoid arthritis and psoriasis.
- Recombinant forms are used to explore mechanisms of chronic inflammation.
- Angiogenesis Research
- CXCL8 is a pro-angiogenic factor, studied for its role in vascular development and wound healing.
CXCL recombinant proteins are versatile tools in research, enabling a deeper understanding of chemokine biology and facilitating the development of targeted therapies for a wide range of diseases.
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