CXXL8 Recombinant Proteins
CXCL8, also known as Interleukin-8 (IL-8), is a chemokine that plays a vital role in the immune response by mediating the recruitment and activation of neutrophils. It is involved in inflammation, angiogenesis, and cancer progression. Recombinant CXCL8 proteins are engineered to mimic the biological properties of the native cytokine, enabling their use in a variety of research and therapeutic applications.
Content on CXCL8 Recombinant Proteins
CXCL8 recombinant proteins are typically expressed in advanced systems such as E. coli or mammalian cells to ensure proper folding and biological activity. Key features include:
- Structure: Available as full-length or functional domains of the CXCL8 protein.
- Purity: High purity (>95%) verified by SDS-PAGE and HPLC analysis.
- Bioactivity: Retains chemotactic activity and receptor-binding functionality (CXCR1 and CXCR2).
Applications of CXCL8 Recombinant Proteins
- Inflammation Research:
- Used to study the role of IL-8 in inflammatory diseases such as arthritis and chronic obstructive pulmonary disease (COPD).
- Assesses CXCL8's effects on neutrophil recruitment and activation.
- Cancer Research:
- Investigates CXCL8-mediated angiogenesis and tumor growth.
- Explores its role in tumor microenvironment and metastasis.
- Functional Assays:
- Utilized in chemotaxis assays to study neutrophil migration.
- Supports receptor-binding studies to evaluate interactions with CXCR1 and CXCR2.
- Drug Development:
- Screens inhibitors targeting the CXCL8-CXCR1/CXCR2 signaling axis for anti-inflammatory and anti-cancer therapies.
CXCL8 recombinant proteins are critical tools in immunology, inflammation, and oncology research. Their ability to retain biological activity and receptor interactions makes them highly valuable for studying disease mechanisms and developing targeted therapies.
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