Dengue Recombinant Proteins
Dengue recombinant proteins are essential tools for the study of the Dengue virus (DENV), a flavivirus responsible for Dengue fever, a global health threat with no specific antiviral treatment. These proteins are synthesized using advanced expression systems to reproduce the structure and functionality of key viral proteins, facilitating research on viral pathogenesis, immune responses, and vaccine development.
Content
- Envelope Protein (E):
- Facilitates viral entry by mediating receptor binding and membrane fusion.
- Contains immunodominant epitopes and is a primary target for neutralizing antibodies.
- NS1 Protein:
- A secreted glycoprotein critical for immune evasion and complement activation.
- Biomarker for early Dengue infection and a target for diagnostic assays.
- NS3 Protein:
- Multifunctional enzyme with helicase, protease, and RNA triphosphatase activity.
- Essential for viral replication and processing of the viral polyprotein.
Applications
- Vaccine Development:
- Used to identify immunodominant epitopes for vaccine design.
- Supports the evaluation of immune responses to candidate vaccines.
- Diagnostic Assays:
- Recombinant NS1 protein is widely used in ELISA and lateral flow assays for early detection of Dengue.
- Envelope and prM proteins serve as antigens in serological assays to determine past exposure.
- Antiviral Drug Discovery:
- NS3 and NS5 proteins are primary targets for high-throughput screening of inhibitors.
- Facilitates studies of viral replication and enzyme activity.
Dengue recombinant proteins are indispensable in advancing diagnostics, therapeutics, and vaccines, addressing the urgent need for effective control and management of Dengue virus infections.
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