EUREG Recombinant Proteins 

EUREG (Epiregulin) is a member of the epidermal growth factor (EGF) family and serves as a ligand for the epidermal growth factor receptor (EGFR/ErbB1) and ErbB4. EUREG plays a significant role in cell proliferation, differentiation, migration, and tissue remodeling. Recombinant EUREG proteins are widely used in studying EGFR signaling pathways, cancer biology, wound healing, and tissue regeneration.

Content

• Structure and Function:
  • EUREG is a small protein with a conserved EGF-like domain.
  • Binds EGFR to activate downstream signaling pathways, including MAPK, PI3K/AKT, and JAK/STAT.
  • Involved in processes such as inflammation, tumor progression, and repair mechanisms.
• Expression Systems:
  • Bacterial Systems (e.g., E. coli): Efficient for producing biologically active EUREG.
  • Mammalian Systems: Preferred for obtaining post-translationally modified EUREG.
  • Insect Cells: Balances scalability and native protein folding.

Applications

• Cancer Research:
  • Investigating the role of EUREG in tumor progression, angiogenesis, and metastasis.
  • Studying EGFR activation in cancers such as colorectal, lung, and breast cancer.
  • Screening inhibitors of EUREG-EGFR interactions for therapeutic development.
• Wound Healing and Tissue Regeneration:
  • Evaluating EUREG's effects on epithelial and fibroblast proliferation during repair.
  • Studying its role in modulating inflammatory responses in damaged tissues.
• Cell Signaling Studies:
  • Elucidating the downstream signaling cascades activated by EUREG-EGFR binding.
  • Investigating cross-talk between EGFR and other receptor pathways.

EUREG recombinant proteins are indispensable for understanding EGFR biology and developing therapeutic strategies targeting EGFR-driven diseases, offering valuable insights into their physiological and pathological roles.