FGF Recombinant Proteins
FGF (Fibroblast Growth Factor) recombinant proteins are members of a family of growth factors critical for cell proliferation, differentiation, angiogenesis, and wound healing. The FGF family includes 22 members, such as FGF1 (acidic FGF), FGF2 (basic FGF), and FGF21, which signal through specific FGF receptors (FGFRs). These proteins play essential roles in embryogenesis, tissue repair, and metabolic regulation, with significant implications in cancer, regenerative medicine, and metabolic disorders.
Content of FGF Recombinant Proteins
FGF recombinant proteins are expressed in bacterial, insect, or mammalian systems to ensure proper folding and activity. They are often provided in tag-free or tagged forms (e.g., His-tag, GST-tag) to facilitate purification and detection. High-purity recombinant FGFs retain their bioactivity and binding affinity for FGFRs, often requiring heparin for enhanced receptor interaction and stability.
Applications of FGF Recombinant Proteins
- Cell Culture and Stem Cell Research
- FGF2 is widely used to maintain pluripotency in embryonic stem cells and support the growth of induced pluripotent stem cells (iPSCs).
- FGFs are essential for culturing specific cell types, including endothelial cells and neural progenitor cells.
- Angiogenesis Studies
- FGFs, particularly FGF2, are used to investigate the mechanisms of blood vessel formation and their role in wound healing and tumor growth.
- Regenerative Medicine
- Studied for their potential in tissue repair, including skin, bone, and neural regeneration.
- Cancer Research
- FGFs and FGFRs are implicated in tumor proliferation, angiogenesis, and metastasis.
- Recombinant FGFs are employed to explore FGF signaling in cancer progression and drug resistance.
- Metabolic Disease Studies
- FGFs like FGF19 and FGF21 are critical regulators of glucose and lipid metabolism, making them targets in diabetes and obesity research.
- Drug Discovery and Screening
- High-throughput assays using recombinant FGFs identify inhibitors of FGF-FGFR interactions for cancer and metabolic disorder treatments.
FGF recombinant proteins are indispensable for advancing research in developmental biology, regenerative medicine, and disease therapeutics. They provide valuable tools for studying cellular processes and developing innovative treatments.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|