GFAP Recombinant Proteins 

Glial Fibrillary Acidic Protein (GFAP) is an intermediate filament protein primarily expressed in astrocytes, providing structural support and playing a vital role in central nervous system (CNS) integrity and function. GFAP recombinant proteins are engineered tools used in studying astrocyte biology, CNS injury, neurodegenerative diseases, and gliomas.

Content

  • Structure and Function:
    • GFAP is a key cytoskeletal component of astrocytes.
    • It exists in multiple isoforms, with GFAP-alpha being the most abundant and widely studied.
    • Dysregulation of GFAP expression and aggregation is implicated in Alexander disease and other CNS disorders.
  • Expression Systems:
    • Bacterial Systems (e.g., E. coli): Efficient for producing non-glycosylated GFAP for biochemical studies.
    • Mammalian Systems: Ideal for functional studies requiring post-translational modifications.
    • Insect Cells: Used for high-yield production with structural integrity.

Applications

  • Neuroscience Research:
    • Investigating astrocyte reactivity in CNS injury and disease.
    • Exploring the role of GFAP in neuroinflammation and neurodegeneration.
    • Assessing GFAP expression and isoform dynamics in brain development and plasticity.
  • Disease Modeling:
    • Studying Alexander disease and other GFAP-related neuropathologies using mutant recombinant proteins.
    • Elucidating aggregation and dysfunction mechanisms associated with GFAP mutations.
  • Structural Biology:
    • Analyzing GFAP filament assembly and interactions with other cytoskeletal components.
    • Investigating post-translational modifications, such as phosphorylation, and their impact on GFAP function.

GFAP recombinant proteins are indispensable in advancing research on astrocyte biology, CNS disorders, and glioma pathology. Their versatility and relevance make them critical tools in neuroscience and therapeutic development.

AffiREC® Recombinant Human GFAP Protein, His Tag
CAT# AFG-KMD-20687
Size: 100 μg
1,488.50 1488.5 USD
559.05 559.0500000000001 USD
AffiREC® GFAP
CAT# AFG-NRM-0073
Size: 100 ul
559.05 559.0500000000001 USD
517.00 517.0 USD
518.50 518.5 USD
983.50 983.5 USD