GHRH Recombinant Proteins 

GHRH (Growth Hormone-Releasing Hormone) recombinant protein is an engineered version of the endogenous peptide hormone responsible for stimulating the release of growth hormone (GH) from the anterior pituitary gland. Produced by hypothalamic neurons, GHRH plays a critical role in regulating growth, metabolism, and cellular proliferation. Recombinant GHRH is utilized extensively in research and therapeutic applications, including studies of endocrine regulation, metabolic disorders, and cancer biology.

Content on GHRH Recombinant Protein

• Structure and Function
  • GHRH is a 44-amino acid peptide hormone that binds to the GHRH receptor on somatotroph cells in the pituitary gland.
  • It activates the cAMP/PKA signaling pathway, promoting growth hormone synthesis and secretion.
  • Recombinant GHRH is typically expressed as the biologically active N-terminal 29 or 44 amino acids of the full-length peptide.
• Expression Systems
  • Prokaryotic Systems (e.g., E. coli): Efficient for producing small peptide forms of GHRH.
  • Eukaryotic Systems (e.g., mammalian or yeast cells): Preserve post-translational modifications and bioactivity required for receptor binding.

Applications of GHRH Recombinant Protein

• Endocrinology Research
  • Study the regulation of growth hormone secretion and its downstream effects on metabolism and growth.
  • Investigate GHRH’s role in the hypothalamic-pituitary-growth axis under normal and pathological conditions.
• Metabolic Studies
  • Examine the effects of GHRH on lipid and glucose metabolism, insulin sensitivity, and energy balance.
  • Explore its therapeutic potential in metabolic disorders such as obesity and diabetes.
• Cancer Research
  • Study the expression and function of GHRH and its receptor in various cancers, including breast, prostate, and lung cancer.
  • Investigate GHRH antagonists as potential therapeutic agents for cancer treatment.
• Growth Disorders
  • Develop and test therapies for growth hormone deficiencies, such as idiopathic short stature and pituitary dwarfism.
  • Analyze the efficacy of GHRH in stimulating endogenous growth hormone production.

GHRH recombinant protein is a versatile tool for advancing research in endocrinology, metabolic science, and cancer therapy, offering critical insights into the regulation and therapeutic modulation of growth hormone activity.