GM- CSF Recombinant Proteins 

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Recombinant Protein is a bioengineered version of the endogenous cytokine that regulates hematopoiesis and immune responses. GM-CSF stimulates the proliferation, differentiation, and activation of granulocytes, macrophages, and dendritic cells, playing a vital role in innate and adaptive immunity. Recombinant GM-CSF is typically expressed in systems like E. coli, yeast, or mammalian cells to ensure high bioactivity and purity.

Content

Recombinant GM-CSF proteins are manufactured via advanced recombinant DNA technology, enabling precise replication of the human or murine cytokine. The process ensures proper folding, disulfide bond formation, and post-translational modifications when produced in mammalian or yeast systems. These proteins are characterized by:

• Purity: ≥ 95%, confirmed via SDS-PAGE and HPLC.
• Activity: Bioassay-verified for colony-stimulating potential.
• Stability: Lyophilized formulations ensure long-term activity after reconstitution.
• Variants: Human, mouse, or other species-specific GM-CSF are available for tailored research needs.

Applications

• Cancer Research:
  • Serves as an adjuvant in cancer immunotherapy by boosting dendritic cell-based vaccines.
  • Evaluates its role in the tumor microenvironment, including recruitment and activation of tumor-associated macrophages.
• Drug Discovery and Development:
  • A critical tool in high-throughput screening for drugs targeting GM-CSF or its receptor.
  • Assesses potential GM-CSF inhibitors in autoimmune and inflammatory diseases.
• Wound Healing and Regeneration:
  • Studies GM-CSF’s ability to promote tissue repair by stimulating macrophage activity and angiogenesis.
• Neuroinflammation and Neurology:
  • Investigates GM-CSF’s role in neuroinflammatory conditions, including multiple sclerosis and neurodegenerative diseases.
• Infectious Disease Research:
  • Models host-pathogen interactions, particularly GM-CSF’s role in enhancing pathogen clearance by macrophages and neutrophils.

Recombinant GM-CSF proteins are indispensable in immunology, oncology, and regenerative medicine, offering critical insights into therapeutic interventions and basic biological processes.