GZMB Recombinant Proteins
GZMB (Granzyme B) recombinant protein is a serine protease primarily secreted by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It plays a critical role in immune-mediated apoptosis by cleaving intracellular substrates in target cells. GZMB is also involved in inflammatory responses and extracellular matrix remodeling, making it a pivotal molecule in immunology, oncology, and inflammation research.
Content of GZMB Recombinant Protein
GZMB recombinant proteins are produced using heterologous expression systems such as E. coli, insect cells, or mammalian cells to ensure high bioactivity and proper folding. These proteins are often provided with tags (e.g., His-tag or GST-tag) to facilitate purification and detection. Recombinant GZMB retains its enzymatic activity and can hydrolyze substrates with aspartic acid at the P1 position, mimicking its natural function.
Applications of GZMB Recombinant Protein
- Immunology Research
GZMB is studied for its role in immune surveillance, cytotoxicity, and inflammatory signaling. - Cancer Biology
Used to investigate CTL- and NK-mediated tumor cell killing, as well as the mechanisms of tumor immune evasion. - Apoptosis Studies
GZMB recombinant protein is employed in in vitro assays to elucidate its role in inducing caspase-dependent and -independent cell death pathways. - Drug Discovery
GZMB serves as a target for screening inhibitors that modulate its activity, particularly for therapeutic applications in autoimmune diseases and transplant rejection. - Inflammation Research
GZMB’s role in non-apoptotic processes, including extracellular matrix remodeling and cytokine activation, is a focus of studies on chronic inflammation and fibrosis. - Pathogen Defense
GZMB is investigated for its involvement in the immune response to viral and bacterial infections.
GZMB recombinant protein is a versatile tool in immunology, oncology, and therapeutic development, providing insights into immune regulation, apoptosis, and disease pathology.
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