HAVCR Recombinant Proteins 

HAVCR (Hepatitis A Virus Cellular Receptor) recombinant proteins, also referred to as TIM (T-cell Immunoglobulin and Mucin domain) proteins, are essential in immunoregulation and cellular signaling. These proteins, including HAVCR1 (TIM-1) and HAVCR2 (TIM-3), are involved in immune responses, pathogen recognition, and tissue homeostasis. They serve as critical mediators in inflammation, autoimmune disorders, and viral infections, particularly in Hepatitis A and other diseases.

Content of HAVCR Recombinant Proteins

HAVCR recombinant proteins are produced in bacterial, insect, or mammalian expression systems to ensure structural and functional integrity. These proteins typically include the extracellular domains responsible for ligand binding and immune signaling. They are often tagged (e.g., His-tag, GST-tag) to facilitate purification and experimental use. Recombinant HAVCR proteins mimic their natural counterparts, retaining ligand-binding and immunoregulatory properties.

Applications of HAVCR Recombinant Proteins

• Viral Infection Studies
  • HAVCR1 is studied as a receptor for Hepatitis A Virus and other pathogens.
  • Investigations focus on viral entry mechanisms and host-pathogen interactions.
• Cancer Immunotherapy
  • HAVCR2 (TIM-3) is a key immune checkpoint protein.
  • Used to study T-cell exhaustion and develop therapeutic antibodies to enhance anti-tumor immunity.
• Autoimmune Disease Research
  • HAVCR proteins are involved in regulating immune tolerance.
  • Recombinant forms are used to investigate their role in conditions like lupus, multiple sclerosis, and rheumatoid arthritis.
• Immune Response Modulation
  • Studied for their role in balancing pro-inflammatory and anti-inflammatory pathways in innate and adaptive immunity.
• Structural Biology
  • Recombinant HAVCR proteins are utilized in structural studies to understand their ligand-binding domains and interaction sites.
• Drug Discovery and Screening
  • High-throughput assays involving HAVCR recombinant proteins help identify small molecules or antibodies targeting immune checkpoints.

HAVCR recombinant proteins are indispensable in immunology and virology research, providing critical insights into immune regulation, pathogen interaction, and therapeutic intervention.