HBV Recombinant Proteins 

HBV recombinant proteins are engineered proteins derived from various components of the Hepatitis B virus (HBV), including the surface antigen (HBsAg), core antigen (HBcAg), and other viral proteins. These recombinant proteins are vital tools for studying HBV infection mechanisms, vaccine development, and serological diagnostics. They provide high purity and biological activity, enabling accurate and reproducible research applications.

Content on HBV Recombinant Proteins

HBV recombinant proteins are synthesized using expression systems such as E. coli, yeast, or mammalian cells, ensuring correct folding and functionality. Key characteristics include:

• Variants: Common forms include HBsAg, HBcAg, HBeAg, and polymerase proteins..
• Expression Systems: Yeast systems for HBsAg and E. coli for core and other non-glycosylated proteins.
• Activity: Retains immunogenic and functional properties for use in assays or structural studies.

Applications of HBV Recombinant Proteins

• Vaccine Development:
  • Recombinant HBsAg is widely used in the production of HBV vaccines.
  • Serves as a platform for designing next-generation vaccines targeting HBV mutations.
• Serological Diagnostics:
  • Used as antigens in ELISA and CLIA kits for detecting anti-HBV antibodies in blood samples.
  • Applied in confirmatory tests for HBsAg, HBcAb, and HBeAb.
• Drug Screening:
  • Facilitates the evaluation of antiviral compounds targeting HBV replication and protein function.
• Immunological Studies:
  • Enables the analysis of host immune responses to HBV infection, particularly T-cell and B-cell responses.

HBV recombinant proteins are indispensable for advancing research into Hepatitis B virus biology and improving diagnostic and therapeutic strategies. Their high-quality production and functional integrity make them essential tools for virology, immunology, and pharmaceutical research.