HDV Recombinant Proteins 

HDV recombinant proteins are laboratory-synthesized proteins derived from the Hepatitis D virus (HDV), a defective RNA virus that requires the Hepatitis B virus (HBV) for its replication and infectivity. These proteins include key viral components such as the large delta antigen (L-HDAg) and small delta antigen (S-HDAg), which are essential for HDV replication and assembly. 

Content on HDV Recombinant Proteins

HDV recombinant proteins are typically expressed using E. coli, yeast, or mammalian cells, ensuring proper folding and functionality. Their production under stringent conditions ensures reproducibility and high purity. Key characteristics include:

• Variants: Common proteins include L-HDAg and S-HDAg, as well as truncated or fusion forms for specific research needs.
• Molecular Weight: Approximately 24-27 kDa for S-HDAg and ~27-30 kDa for L-HDAg.
• Expression Systems:
  • E. coli for cost-effective production of non-glycosylated forms.
  • Mammalian systems for proteins requiring post-translational modifications.

Applications of HDV Recombinant Proteins

• Diagnostics:
  • Used as antigens in ELISA, Western blot, and other serological assays to detect anti-HDV antibodies or HDV antigens in patient samples.
• Vaccine Development:
  • Investigates immune responses to HDV antigens for the development of prophylactic or therapeutic vaccines.
• Drug Screening:
  • Facilitates the screening of antiviral agents targeting HDV replication and interaction with HBV.

HDV recombinant proteins are indispensable for advancing the understanding of Hepatitis D virus pathogenesis and its interaction with HBV. Their high-quality production ensures reliability in applications ranging from diagnostics to vaccine development and antiviral drug discovery, making them vital resources in HDV research.