HTR Recombinant Proteins
HTR (5-Hydroxytryptamine Receptor) recombinant proteins are synthesized to mimic the structural and functional properties of serotonin receptors, which belong to the G-protein-coupled receptor (GPCR) family or ligand-gated ion channels. These proteins are critical in studying serotonin signaling pathways involved in neurological, cardiovascular, and gastrointestinal functions.
Content on HTR Recombinant Proteins
- Structure and Types
HTR receptors are classified into seven families (HTR1–HTR7), with subtypes based on their genetic and functional diversity. These receptors mediate serotonin (5-HT) signaling and are involved in various physiological processes:- HTR1 and HTR5: Coupled to Gi/o proteins, inhibit adenylate cyclase.
- HTR2: Coupled to Gq/11 proteins, stimulate phospholipase C.
- HTR3: Ionotropic, functioning as ligand-gated ion channels.
- HTR4, HTR6, HTR7: Coupled to Gs proteins, activate adenylate cyclase.
- Key Features
- High fidelity in mimicking receptor-ligand interactions.
- Available with tags for detection and purification (e.g., His-tag, GST-tag).
Applications of HTR Recombinant Proteins
- Pharmacological Studies
- Drug Screening: Evaluate agonists, antagonists, and allosteric modulators for therapeutic interventions in disorders such as depression, anxiety, and schizophrenia.
- Binding Assays: Investigate ligand-receptor interactions and signaling mechanisms.
- Cardiovascular Research
- Investigate the role of HTRs in vascular tone regulation and platelet aggregation, particularly HTR2 and HTR3.
- Explore receptor involvement in hypertension and arrhythmias.
- Gastrointestinal Studies
- Examine serotonin-mediated signaling in gut motility and secretion via HTR3 and HTR4.
- Study disorders like irritable bowel syndrome (IBS) and nausea.
HTR recombinant proteins provide essential tools for decoding serotonin receptor biology, paving the way for novel therapeutic strategies in neurological, cardiovascular, and gastrointestinal diseases.
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