KIAA Recombinant Proteins 

KIAA recombinant proteins refer to a group of proteins encoded by genes initially identified through large-scale sequencing projects in humans. The KIAA nomenclature represents genes with unknown functions at the time of discovery. These proteins are involved in various cellular processes, including signal transduction, cytoskeletal organization, and transcriptional regulation. KIAA proteins often serve as markers or functional components in disease-related research, particularly cancer, neurodegeneration, and developmental disorders.

Content of KIAA Recombinant Protein

KIAA recombinant proteins are expressed in prokaryotic or eukaryotic systems to preserve structural and functional properties. These proteins are typically produced with affinity tags (e.g., His-tag, GST-tag) for ease of purification and detection. Many KIAA proteins, such as KIAA0101 (PAF15) and KIAA1524 (CIP2A), have been linked to critical cellular pathways and pathological conditions, making their recombinant forms crucial for targeted studies.

Applications of KIAA Recombinant Protein
  • Cancer Research
    Proteins like KIAA1524 (CIP2A) are studied for their role in tumorigenesis, as they are implicated in oncogenic signaling pathways and drug resistance.
  • Neurodegenerative Disease Studies
    Some KIAA proteins are associated with neuronal function and are investigated for their potential roles in neurodegenerative disorders.
  • Protein-Protein Interaction Studies
    Recombinant KIAA proteins are used to identify and characterize interactions with other proteins, elucidating their roles in cellular pathways.
  • Structural Biology
    KIAA recombinant proteins facilitate structural studies, including X-ray crystallography and NMR, to understand their domain architecture and molecular functions.
  • Drug Discovery and Screening
    These proteins are employed in high-throughput screening assays to identify small molecules that modulate their activity, particularly in cancer and metabolic diseases.
  • Developmental Biology
    KIAA proteins involved in cellular differentiation and development are used in functional studies to uncover mechanisms underlying developmental disorders.
  • Assay Development
    Recombinant forms are utilized for developing diagnostic tools and functional assays in translational research.

KIAA recombinant proteins are indispensable for studying diverse biological pathways and disease mechanisms, making them valuable tools in molecular and biomedical research.