KIIIB Recombinant Proteins 

KIIIB recombinant proteins are engineered versions of proteins derived from Protein Kinase IIIB (also referred to as Casein Kinase IIIB or related variants). These proteins are serine/threonine kinases involved in various cellular signaling pathways, including those regulating cell growth, differentiation, apoptosis, and stress responses. 

Content on KIIIB Recombinant Proteins

• Structure and Function
  • KIIIB is a member of the protein kinase family, characterized by:
    • Catalytic Domain: Responsible for ATP binding and phosphorylation of substrates.
    • Regulatory Regions: Modulate activity through interactions with cofactors or post-translational modifications.
  • Plays roles in:
    • Phosphorylation of intracellular proteins, including transcription factors, metabolic enzymes, and cytoskeletal components.
    • Modulating signal transduction pathways linked to cellular stress and survival.

Applications of KIIIB Recombinant Proteins

• Signal Transduction Research
  • Study the role of KIIIB in phosphorylation events that regulate cell signaling cascades.
  • Analyze its involvement in cross-talk between multiple pathways, including stress and survival signaling.
• Cancer Research
  • Investigate dysregulated KIIIB activity in tumorigenesis and cancer progression.
  • Explore KIIIB as a therapeutic target for developing kinase inhibitors in oncology.
• Neurobiology Studies
  • Study the role of KIIIB in neuronal signaling, synaptic plasticity, and neuroprotection.
  • Investigate its dysregulation in neurodegenerative diseases like Alzheimer’s and Parkinson’s.
• Drug Discovery and Screening
  • Screen small-molecule inhibitors or activators targeting KIIIB kinase activity.
  • Develop structure-based drugs by studying KIIIB-ligand interactions.

KIIIB recombinant proteins are essential tools for advancing research in kinase signaling, disease mechanisms, and drug development, providing valuable insights into cellular regulation and potential therapeutic targets.