MDC Recombinant Proteins 

MDC (Macrophage-Derived Chemokine) recombinant proteins refer to engineered versions of the chemokine CCL22, a member of the CC chemokine family. MDC is secreted by dendritic cells, macrophages, and monocytes and plays a critical role in immune regulation by attracting T cells, natural killer (NK) cells, and dendritic cells via the CCR4 receptor.

Content on MDC Recombinant Proteins
  • Structure and Function
    • MDC/CCL22 is a small protein of approximately 8 kDa, with a conserved cysteine motif critical for receptor binding and signaling.
    • It binds specifically to CCR4, promoting chemotaxis and modulating immune responses.
    • Plays a role in:
      • Recruiting regulatory T cells (Tregs) to inflammatory sites.
      • Mediating immune suppression in cancer.
      • Contributing to allergic and inflammatory disorders.
  • Expression Systems
    • Prokaryotic Systems (e.g., E. coli): Cost-effective for producing non-glycosylated forms.
    • Eukaryotic Systems (e.g., mammalian or insect cells): Necessary for proper folding and post-translational modifications.
Applications of MDC Recombinant Proteins
  • Cancer Research
    • Study MDC-mediated recruitment of Tregs and its role in immune evasion by tumors.
    • Explore MDC as a potential biomarker for tumor progression or immune suppression in cancers like lymphoma and melanoma.
  • Autoimmune and Allergic Diseases
    • Examine MDC’s role in conditions like atopic dermatitis, asthma, and rheumatoid arthritis, where immune cell recruitment is dysregulated.
    • Develop inhibitors targeting MDC-CCR4 interactions to modulate pathological inflammation.
  • Drug Discovery and Screening
    • Screen for small molecules, antibodies, or biologics that block MDC-CCR4 interactions for therapeutic development.
    • Test MDC’s role in modulating immune responses for potential immunotherapies.

MDC recombinant proteins are invaluable tools for advancing research into immune regulation, offering critical insights into the mechanisms of inflammation, cancer immunology, and therapeutic targeting of chemokine pathways.