MGP Recombinant Proteins 

MGP (Matrix Gla Protein) recombinant protein is an engineered form of the extracellular matrix protein that plays a crucial role in inhibiting vascular calcification and maintaining normal bone mineralization. MGP is a vitamin K-dependent protein that binds calcium ions and hydroxyapatite, making it essential for regulating mineralization in tissues. Recombinant MGP proteins are widely used in cardiovascular, bone biology, and metabolic research.

Content on MGP Recombinant Protein
  • Structure and Function
    • Calcium-binding Properties: MGP binds calcium ions via gamma-carboxylated glutamate (Gla) residues, requiring vitamin K-dependent post-translational modification for activation.
    • Inhibition of Calcification: MGP prevents ectopic calcification in soft tissues and vascular systems by binding to hydroxyapatite crystals.
    • Regulation of Bone Mineralization: Plays a role in the balance between bone formation and resorption.
Applications of MGP Recombinant Protein
  • Cardiovascular Research
    • Study MGP’s role in preventing vascular calcification in conditions like atherosclerosis and chronic kidney disease (CKD).
    • Investigate MGP as a potential biomarker for cardiovascular health and disease progression.
  • Bone Biology Studies
    • Explore the role of MGP in regulating bone mineral density and preventing osteoporosis.
    • Analyze MGP interactions with bone matrix proteins and its impact on bone remodeling.
  • Metabolic and Endocrine Research
    • Examine the effects of vitamin K on MGP activation and its implications in metabolic diseases.
    • Study MGP’s role in regulating mineral metabolism in various tissues.
  • Drug Discovery and Screening
    • Test small molecules or biologics that modulate MGP activity to treat vascular calcification and bone disorders.
    • Screen vitamin K analogs for their ability to activate MGP in therapeutic settings.

MGP recombinant proteins are essential tools for understanding the molecular mechanisms of calcification and mineralization, providing critical insights into potential therapeutic targets for cardiovascular and bone-related disorders.

398.50 398.5 USD
398.50 398.5 USD