PRG Recombinant Proteins 

PRG (Proteoglycan) recombinant proteins are critical for investigating the roles of proteoglycans in cellular signaling, matrix interactions, and tissue homeostasis. Proteoglycans, composed of a core protein and covalently attached glycosaminoglycan (GAG) chains, are integral components of the extracellular matrix (ECM). They modulate cell adhesion, migration, growth factor activity, and inflammatory responses. PRG proteins, including those like PRG1 (Plasticity-Related Gene 1), are of particular interest for their roles in neural plasticity, injury recovery, and cancer biology.

Content of PRG Recombinant Protein

PRG recombinant proteins are synthesized in bacterial, yeast, or mammalian systems to ensure proper folding and activity. Depending on the specific proteoglycan, recombinant production may include or exclude GAG modifications. These proteins are available in tagged forms (e.g., His-tag, GST-tag) for ease of purification and downstream analysis. PRG recombinant proteins are often tailored to retain functional domains critical for ligand interactions and biological activity.

Applications of PRG Recombinant Protein

• Neuroscience Research
  PRG1 and related proteins are studied for their roles in synaptic plasticity, neural regeneration, and axonal growth.
• Cancer Biology
  Proteoglycans such as syndecans and glypicans, produced as PRG recombinant proteins, are investigated for their roles in tumor growth, angiogenesis, and metastasis.
• Extracellular Matrix (ECM) Studies
  Used to explore ECM remodeling, cell-matrix interactions, and tissue-specific signaling pathways.
• Inflammation and Immunology
  PRG proteins modulate inflammatory responses by interacting with cytokines, chemokines, and immune receptors, making them valuable for studying immune regulation.
• Drug Discovery
  Recombinant PRG proteins serve as targets for screening inhibitors or modulators of proteoglycan-mediated signaling pathways in diseases like cancer and fibrosis.
• Structural Biology
  PRG proteins facilitate structural and functional studies, including crystallography and binding assays, to elucidate their interaction with ligands or receptors.
• Regenerative Medicine
  PRG recombinant proteins are studied for their roles in tissue repair and regeneration, particularly in cartilage and neural tissues.

PRG recombinant proteins provide invaluable insights into the molecular mechanisms of proteoglycan function and are essential tools in research areas spanning neuroscience, oncology, and regenerative medicine.