Ptpn Recombinant Proteins 

PTPN (Protein Tyrosine Phosphatase Non-receptor) recombinant proteins represent a class of engineered enzymes that play a pivotal role in regulating cellular signal transduction pathways. As part of the protein tyrosine phosphatase family, PTPN proteins are crucial for dephosphorylating tyrosine residues in proteins, balancing phosphorylation-driven signaling in processes like cell growth, differentiation, and immune responses.

Content of PTPN Recombinant Protein

PTPN recombinant proteins are produced through heterologous expression systems (e.g., bacterial, insect, or mammalian cells) to ensure high activity and structural integrity. These proteins may include affinity tags such as His-tag or GST for simplified purification and analysis. Examples of PTPN family members include PTPN1 (PTP1B), which regulates insulin signaling, and PTPN11 (SHP-2), involved in the RAS/MAPK pathway.

Applications of PTPN Recombinant Protein

• Signal Transduction Research
  Used to study their role in regulating pathways such as insulin signaling, immune cell activation, and growth factor receptor pathways.
• Cancer Research
  PTPN11 (SHP-2) is a key target in oncogenic signaling pathways, making recombinant forms valuable for drug screening and pathway analysis.
• Metabolic Disorders
  PTPN1 (PTP1B) is implicated in obesity and type 2 diabetes, and recombinant proteins are employed in developing inhibitors to improve insulin sensitivity.
• Structural Biology
  Recombinant PTPN proteins are used for crystallography and biochemical assays to elucidate their catalytic mechanisms and identify allosteric sites.
• Therapeutic Screening
  High-throughput screening assays for small-molecule modulators of PTPN activity use recombinant proteins as key components.
• Immune System Research
  PTPN family members are involved in T-cell and B-cell signaling; recombinant proteins help decipher mechanisms of immune regulation.

PTPN recombinant proteins are integral to the study of phosphorylation-dependent cellular processes and offer significant potential in developing targeted therapeutics for diseases involving dysregulated signaling pathways.