SERPINC Recombinant Proteins 

SERPINC (Serpin Family C Member 1) recombinant protein, also known as antithrombin III (ATIII), is a critical serine protease inhibitor involved in the regulation of blood coagulation. It primarily inactivates thrombin and other clotting factors such as Factor Xa, IXa, and XIa, preventing excessive clot formation. Recombinant SERPINC proteins are valuable in research, therapeutic development, and diagnostics related to coagulation disorders, thrombosis, and anticoagulant therapy.

Content on SERPINC Recombinant Protein

• Structure and Function
  • SERPINC is a glycoprotein comprising approximately 432 amino acids.
  • It functions by forming a stable complex with target proteases, rendering them inactive.
  • The activity of SERPINC is significantly enhanced in the presence of heparin, leading to a ~1000-fold increase in its anticoagulant properties.
• Expression Systems
  • Prokaryotic Systems (e.g., E. coli): Used for non-glycosylated forms; suitable for functional studies focused on the serpin mechanism.
  • Eukaryotic Systems (e.g., mammalian or insect cells): Essential for producing glycosylated SERPINC with native activity and stability.

Applications of SERPINC Recombinant Protein

• Coagulation Research
  • Study the role of SERPINC in the regulation of blood coagulation and fibrinolysis.
  • Investigate its interactions with thrombin, Factor Xa, and heparin in coagulation cascades.
• Thrombosis and Hemostasis Studies
  • Explore the mechanisms of antithrombin deficiency in inherited or acquired thrombophilia.
  • Study the effects of SERPINC mutations on its anticoagulant function and stability.
• Therapeutic Development
  • Develop recombinant antithrombin products for treating hereditary antithrombin deficiency and related conditions.
  • Screen for small molecules or biologics that enhance or mimic SERPINC activity as anticoagulant therapies.

SERPINC recombinant protein is a critical resource for understanding and developing treatments for coagulation disorders, offering insights into its mechanisms and applications in anticoagulation therapy and diagnostics.