Synuclein Recombinant Proteins 

Synuclein recombinant proteins, particularly alpha-synuclein (α-synuclein), are critical for studying neurodegenerative diseases such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Synucleins are small, soluble proteins primarily expressed in neural tissue and are implicated in synaptic function, vesicle trafficking, and cellular signaling. Misfolded synuclein aggregates are hallmarks of several neurodegenerative disorders.

Content of Synuclein Recombinant Protein

Synuclein recombinant proteins are typically expressed in prokaryotic or eukaryotic systems to ensure proper folding and post-translational modifications (if required). High-purity recombinant α-synuclein is commonly used in research, but other isoforms, such as beta-synuclein (β-synuclein) and gamma-synuclein (γ-synuclein), are also available. Proteins can be labeled (e.g., His-tagged) or untagged, depending on the intended application.

Applications of Synuclein Recombinant Protein

• Neurodegenerative Disease Research
  Recombinant α-synuclein is used to study its aggregation kinetics and toxic forms in diseases like Parkinson's and DLB.
• Drug Screening
  Used in high-throughput assays to identify compounds that inhibit α-synuclein aggregation or promote its clearance.
• Structural and Biophysical Studies
  Synuclein proteins are studied to understand their conformational dynamics, aggregation mechanisms, and interactions with lipids and other cellular components.
• Pathology Modeling
  Recombinant proteins are used to create in vitro and in vivo models of synucleinopathies, enabling the study of disease progression and therapeutic interventions.
• Protein-Protein Interaction Studies
  To investigate the interactions of synuclein with other proteins, such as tau and ubiquitin, which are relevant to neurodegenerative pathways.
• Antibody Validation and Assay Development
  Synuclein recombinant proteins are essential for the development and validation of diagnostic assays and therapeutic antibodies.
• Mitochondrial Function Research
  Used to explore synuclein’s role in mitochondrial dysfunction and oxidative stress, which are key features of neurodegeneration.

Synuclein recombinant proteins are indispensable tools for advancing the understanding of synaptic biology, protein misfolding, and the mechanisms underlying neurodegenerative diseases.