TGFBR Recombinant Proteins 

TGFBR (Transforming Growth Factor Beta Receptor) recombinant proteins represent key components of the TGF-β signaling pathway, which regulates critical cellular processes such as proliferation, differentiation, migration, and apoptosis. These receptors, including TGFBR1 and TGFBR2, are serine/threonine kinases that mediate the effects of TGF-β ligands. Dysregulation of TGFBR activity is implicated in various diseases, including cancer, fibrosis, and autoimmune disorders.

Content of TGFBR Recombinant Proteins

TGFBR recombinant proteins are produced in heterologous systems, such as bacterial, insect, or mammalian cells, to ensure functional folding and activity. They typically include extracellular domains (ECD) for ligand-binding studies or kinase domains for signaling research. These proteins are often tagged (e.g., His-tag, GST-tag) for ease of purification and application. Functional recombinant TGFBRs retain their ability to bind TGF-β ligands and activate downstream SMAD-dependent or independent pathways.

Applications of TGFBR Recombinant Proteins

• Signal Transduction Research
  • Study the mechanisms of TGF-β signaling, including SMAD phosphorylation and activation of non-canonical pathways.
• Cancer Research
  • Investigate the dual role of TGFBR in tumor suppression and promotion, particularly in epithelial-mesenchymal transition (EMT) and metastasis.
• Fibrosis Studies
  • TGFBR proteins are critical in understanding fibrotic diseases by analyzing the activation of TGF-β signaling in tissue remodeling and extracellular matrix deposition.
• Autoimmune and Inflammatory Disease Research
  • Explore the role of TGFBR in immune regulation and its impact on diseases such as lupus, rheumatoid arthritis, and inflammatory bowel disease.
• Drug Discovery and Screening
  • Recombinant TGFBR kinase domains are used in high-throughput assays to identify small-molecule inhibitors targeting TGF-β signaling.
• Ligand-Receptor Interaction Studies
  • Recombinant extracellular domains are utilized to study ligand-binding specificity and affinity, aiding in the design of receptor-blocking therapeutics.

TGFBR recombinant proteins are vital tools for advancing our understanding of TGF-β biology and developing novel therapeutic strategies for diseases involving aberrant TGF-β signaling.