TNFRSF10B Recombinant Proteins 

TNFRSF10B, also known as Tumor Necrosis Factor Receptor Superfamily Member 10B, is a critical member of the TNF receptor superfamily. This receptor, also referred to as DR5, TRICK2, or KILLER, primarily mediates apoptotic signaling in response to the TNF-related apoptosis-inducing ligand (TRAIL). TNFRSF10B plays a pivotal role in regulating cell death, immune surveillance, and tumor suppression pathways.

Content of TNFRSF10B Recombinant Protein

• Structure:
  • The recombinant TNFRSF10B protein typically includes the extracellular domain of DR5, expressed in systems such as E. coli, HEK293, or CHO cells.
  • It is purified to high purity levels (≥95%) using advanced chromatographic techniques, ensuring functionality and structural integrity.
• Physical Properties:
  • Molecular Weight: Approximately 25–35 kDa, depending on the expression system and post-translational modifications.
  • Storage: Stable at −20°C or −80°C in a buffer containing cryoprotectants to maintain activity.
  • Activity: Retains functional binding to TRAIL, enabling downstream apoptotic signaling.

Applications of TNFRSF10B Recombinant Protein

• Cancer Research:
  • Used to investigate TRAIL-induced apoptotic pathways in cancer cells.
  • Enables screening for potential therapeutic compounds targeting the DR5 receptor.
  • Supports the study of tumor immune evasion mechanisms.
• Drug Development:
  • Serves as a model protein for developing TRAIL receptor agonists or DR5-targeted therapies.
  • Functional in preclinical studies involving apoptosis-inducing drugs.
• Cell Biology and Signal Transduction Studies:
  • Facilitates the dissection of TRAIL-mediated signal transduction cascades.
  • Used to study crosstalk between apoptotic and non-apoptotic pathways in various cell types.
• Therapeutic Applications:
  • May be incorporated into antibody-drug conjugates (ADCs) or fusion proteins for targeted cancer therapy.
  • Investigated in combination therapies to sensitize resistant tumors to apoptosis.

Recombinant TNFRSF10B proteins are indispensable tools in apoptosis research and hold significant promise in the development of targeted cancer therapies. Their consistent quality and high functional activity make them an excellent choice for both academic and industrial research settings.